By H. C. Pitot (auth.), Colin S. Cooper Ph.D., Philip L. Grover D.Sc. (eds.)
I were privileged to witness and perform the good development of data on chemical carcinogenesis and mutagenesis when you consider that 1939 whilst I entered graduate university in biochemistry on the collage of Wisconsin Madison. I instantly began to paintings with the carcinogenic aminoazo dyes un der the course of Professor CARL BAUMANN. In 1942 I joined a fellow graduate pupil, ELIZABE1H CAVERT, in marriage and we quickly started out a joyous half nership in study on chemical carcinogenesis on the McArdle Laboratory for melanoma study within the college of Wisconsin clinical university in Madison. This collaboration lasted forty five years. i'm very thankful that this quantity is dedi cated to the reminiscence of Elizabeth. the $64000 and sundry subject matters which are reviewed right here attest to the ongoing development of the fields of chemical vehicle cinogenesis and mutagenesis, together with their fresh and fruitful union with viral oncology. i think very confident concerning the software of data in those fields to the eventual answer of diverse difficulties, together with the detection and estimation of the hazards to people of environmental chemical cancer causing agents and re lated factors.
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Extra info for Chemical Carcinogenesis and Mutagenesis I
The characteristics of progression as defined in multistage carcinogenesis can be seen in Table 1. The irreversibility of this stage is assumed because of the obvious accompanying alterations in the cell genome distinguishing it from the reversible, preceding stage of promotion. However, it is clear that under certain circumstances cells in the stage of progression may be induced, by treatment with specific chemicals, into terminal differentiation, thereby removing them from continued progression to an even more malignant state (REISS et al.
Cancer Treat Rep 70:201-218 Riggs AD, Jones PA (1983) 5-Methy1cytosine, gene regulation, and cancer. Adv Cancer Res 40:1-30 Rous P, Kidd JG· (1941) Conditional neoplasms and subthreshold neoplastic states. A study oftar tumors in rabbits.
1978). That the period of DNA synthesis itself is critical for the "fixation" and thus irreversibility of initiation has been demonstrated in other systems both in vivo and in vitro (WARWICK 1971; FREI and RITCHIE 1963; MCCORMICK and BERTRAM 1982; BOREK and SACHS 1968). As yet, single initiated cells cannot be unequivocally identified by known methodologies, although a recent report by MOORE and his associates (1987) suggested that single hepatocytes exhibiting the presence of the marker placental glutathione-S-transferase in liver represent initiated hepatocytes.