By L. F. Bélanger, T. Semba, S. Tolnai, D. H. Copp, L. Krook, C. Gries (auth.), H. Fleisch, H. J. J. Blackwood, M. Owen (eds.)
The papers amassed during this quantity signify the formal lawsuits of the 3rd ecu Symposium on Calcified Tissues which was once held in Davos, Switzerland from eleventh to sixteenth April 1965 below the sponsorship of the Laboratorium fur experi mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos. This Symposium fol lowed the now tested culture of the former Symposia held in Oxford in 1963 and in Liege in 1964. Participation used to be back strictly on a residential hasis. This 12 months the Schatzalp lodge supplied a scenic and secluded assembly position excessive on a mountain facet overlooking Davos but with regards to the Forschungsinstitut during which the outlet consultation of the Symposium used to be held. The papers and communications released within the quantity are prepared so as of presentation and are grouped less than the 5 major subject matters chosen for dialogue by means of the Symposium, specifically, "Cell functionality within the formation, upkeep and destruc tion of osseous tissue", "Response of calcified tissues to mechanical factors", "Mecha nisms of mineralization and ailments with regards to mineral deposition", "Hormones and bone" and "Fundamental constitution of dental demanding tissues". The programme consisted of a couple of assessment lectures given by way of invited audio system and of brief communications on the subject of all the above topics. No try out was once made to list the dis cussions to the papers as, being a residential assembly, the extra useful and curiosity ing interchanges came about informally in small chat groups and never in the time time table of the prearranged programme.
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Additional info for Calcified Tissues 1965: Proceedings of the Third European Symposium on Calcified Tissues
497. Remodelling of the Bone Matrix 31 HARKNEss, R. : Biologica! functions of collagen. Biol. Rev. 36, 399 (1961). -,A. M. MARKO, H. M. MuiR, and A. NEuBERGER: The metabolism of collagen and other proteins of the skin of rabbits. Biochem. ]. 56, 558 (1954). HAY, E. , and ]. P. REVEL: Autoradiographic studies of the origin of the basement lam el! a in Amblyostoma. Develop. Biol. 7, 152 (1963). , et L. 'os etudiee l'aide du Ca-45. VII. Activite comparee de fractions d'os total de densite differente.
7. His surprise does not primarily concern a possible controversy with HEKKELMAN's data but far more a seeming incompatibility of a PTE induced increase of NADP and the well established PTE induced increase of citrate concentration in bone. ) In fact in VAN REEN's opinion the "old" concept of a metabolic block at the Isocitric dehydrogenase level cannot be considered as the final answer in explaining the accumulation of citrate in bone. In trying to reflect a little upon this new situation it is good to keep in mind, that in most organs NADP is present mainly in the reduced state, the reverse being true for NAD.
From these experiments it is obvious that the donor tissue has indeed the potency to form bone. However, this result does not prove that in grafts the donor tissue also produces bone. In order to get some information on this point donor cells were made distinguishable from host cells by labelling the donor tissue with 3H-thymidine prior to transplantation; in this way the fate of the donor cells during their presence in the host could be determined. Under these circumstances, we have to take into account the possibility that a donor cell could release its labei when dying, and a host cell could then pick up the labei.