By Juliet Compston, Elizabeth Shane

Bone disorder, rather osteoporosis, has emerged as a standard and severe worry of sturdy organ transplantation. lately there were actual advances in our realizing of the pathogenesis and pathophysiology of bone loss, even though remedy stories were quite sparse and winning techniques to minimize skeletal morbidity after transplantation stay to be essentially confirmed. This e-book offers a special source for the various health and wellbeing execs concerned with transplantation of bone sickness, either when it comes to its clinical history and the administration of the sickness in medical perform. Contents: -Basic Transplantation and Bone Biology -Pathogenesis of Transplantation similar Bone illness -Clinical positive factors of Transplantation Bone illness -Management

Show description

Read or Download Bone Disease of Organ Transplantation PDF

Best biophysics books

Molekulare Pharmakologie und Toxikologie: Biologische Grundlagen von Arzneimitteln und Giften

Wie wirkt ein Medikament oder ein present in der Zelle? Thomas Efferth spannt einen Bogen von den allgemeinen Grundlagen der Pharmakologie und Toxikologie zu den molekularen Wirkmechanismen der wichtigsten Medikamente und Gifte. Aktuelle Themen wie Gentherapie, Immuntherapie und Stammzelltherapie behandelt er ebenso wie Pharmakogenetik und –genomik oder systembiologische Ans?

Additional resources for Bone Disease of Organ Transplantation

Example text

11. Khosla, S. (2001). Minireview: the OPG/RANKL/RANK system. Endocrinology. 142(12):5050–5. 12. , et al. (1998). The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells. J Biol Chem. 273(7):4119–28. 13. , et al. The osteopetrotic mutation toothless (tl) is a loss-offunction frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification.

The Copyright 2005, Elsevier Inc. All rights reserved. 47 48 3 Skeletal Effects of Glucocorticoids: Basic and Clinical Aspects increased bone resorption is secondary to effects of glucocorticoids on mineral metabolism and skeletal cells (see Table 1). In addition, patients receiving glucocorticoids often have an underlying inflammatory disease that by itself carries a risk of osteoporosis, and the mechanisms often involve the secretion of bone-resorbing cytokines. Glucocorticoids decrease calcium absorption in the gastrointestinal system, causing resistance to vitamin D, and they increase the urinary excretion of calcium [8].

Circulation. 100:II229–235. 107. , et al. (1996). Indirect recognition of donor HLA-DR peptides in organ allograft rejection. J Clin Invest. 98:1150–1157. 108. D. (1996). Epitope spreading. Curr Opin Immunol. 8:831–836. 109. , et al. (1997). New strategies for early diagnosis of heart allograft rejection. Transplantation. 64:842–847. 110. , Suciu-Foca, N. (1998). Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts. J Clin Invest. 101:398–405. References 29 111.

Download PDF sample

Rated 4.97 of 5 – based on 32 votes