By John D. Robertson, Joya Chandra, Vladimir Gogvadze (auth.), Patrick M. Dansette, Robert Snyder, Marcel Delaforge, G. Gordon Gibson, Helmut Greim, David J. Jollow, Terrence J. Monks, I. Glenn Sipes (eds.)

This quantity offers a dialogue of the organic results produced following the metabolism of xenobiotic chemical substances to chemically reactive metabolites, i.e., poisonous and carcinogenic results, which were the foundation of all 5 prior volumes during this sequence. particularly, this quantity devotes sections to structure-activity relationships, fresh advances within the realizing of the chemistry of reactive metabolites, and the new release and job of reactive oxygen species with precise emphasis on nitric oxide. There also are segments on DNA harm through reactive metabolites and DNA fix, tissue particular responses to BRIs, and human wellbeing and fitness results of BRIs. The papers that include this quantity have been submitted through international classification scientists who have been in attendance on the Symposium on organic Reactive Intermediates VI on the Université René Descartes, July 16-20, 2000.

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Liehr. Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids. 1. BioI. Chem. 269: 292 (1994). 2l. P. Spencer, G. Chowrimootoo, R. S. K. Srai and C. Rice-Evans. The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett. 458: 224 (1999). 22. G. Williamson, AJ. W. Plumb and D. Couteau, Human metabolic pathways of dietary flavonoids and cinnamates. Biochem. Soc. Transact. 28: 16 (2000). 23. M. P. Peters and J. Noordhoek. Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines.

Sergediene, K. Jonsson, H. Szymusiak, B. M. Rietjens and N. Cenas, Prooxidant toxicity of polyphenolic antioxidants to HL-60 cells: description of quantitative structure-activity relationships. FEBS Lett. 462: 392 (1999). 19. K. Shimoi, H. Okada, M. Furugori, T. Goda, S. Takase, M. Suzuki, Y. Hara, H. Yamamoto and N. Kinae. Intestinal absorption of luteolin and luteolin 7 -O-beta-glucoside in rats and humans. FEBS Lett. 438: 220 (1998). 20. T. L. G. Liehr. Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids.

Board et ai. (1997) proposed, from sequence analysis and homology modeling of the N-terminal domain of GSTl-1, possible involvement of a serine (Ser-14) or other polar residue (such as tyrosine) in catalytic function. The likelihood of one or more H-bondingcapable polar residues in the active site, coupled with the apparent requirement of an acid moiety in GSTZ substrates, led us to propose that polarization of the acid carbonyl bond might be directly involved in catalytic enhancement of glutathione conjugation with the ahaloacids.

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