By Peter J. Barnes DM FRS FMedSci, Jeffrey M. Drazen, Stephen I. Rennard, Neil C. Thomson

The second one version of bronchial asthma and COPD: simple Mechanisms and scientific administration keeps to supply a special and authoritative comparability of bronchial asthma and COPD. Written and edited by means of the world's best specialists, it is still a accomplished overview of the newest knowing of the elemental mechanisms of either stipulations, in particular evaluating their etiology, pathogenesis, and coverings.
* every one bankruptcy considers bronchial asthma and COPD in side-by-side distinction and comparability - now not in isolation - within the context of mechanism, triggers, tests, cures, and scientific management
* offers the most recent and such a lot accomplished understandings of the mechanisms of irritation in either bronchial asthma and COPD
* so much broad connection with fundamental literature on either bronchial asthma and COPD in a single source.
* Easy-to-read summaries of the most recent advances along transparent illustrations

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Extra resources for Asthma and COPD, Second Edition: Basic Mechanisms and Clinical Management

Sample text

However, several studies in which the techniques to assess lung function in infants, described earlier, were used showed that children who developed lower respiratory symptoms during viral infections in early life had diminished pre-illness levels of lung function [18, 56, 59]. The hypothesis was thus suggested that lower levels of lung function observed after lower respiratory illnesses in early life could be explained by preexisting diminished lung function, the latter being therefore the link between early life episodes of airway obstruction and subsequent deficits in lung function.

2). The great majority of infants who wheeze during the first 1–2 years of life do so during viral infections, especially those caused by the respiratory syncytial virus (RSV) and by rhinovirus. Most of these children will have one or only a few episodes of wheezing, with no further symptoms beyond the age of 2–3 years. This condition, which has been identified as transient wheezing of infancy [16], is the most frequent form of recurrent airway obstruction in this age group, affecting over two-thirds of all infants with asthmalike symptoms.

Children enrolled in the Melbourne study were divided at the time of enrollment into five groups according to their previous history of wheezing: a control group (no wheezing), a group with mild wheezy bronchitis (less than five lifetime episodes of wheezing associated with colds), a group with wheezy bronchitis (five or more such episodes), a group with asthma (wheezing apart from colds), and a group with severe asthma (selected at age 10 based on severe impairment of lung function). At age 42 years, less than a quarter of children with either form of wheezy bronchitis showed frequent asthma episodes (wheezing during the previous 3 months, but less than once a week) or persistent asthma (once a week or more).

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