By Johannes Ring

Anaphylaxis is the main dramatic and almost certainly life-threatening manifestation of an immediate-type allergy response. even if recognized for over a hundred years, it nonetheless poses many unresolved questions, and its sensible administration and acute remedy are frequently extra empiric in nature than evidence-based. during this publication, a multidisciplinary team of specialists assessment the cutting-edge within the pathophysiology, epidemiology, analysis and scientific symptomatology of anaphylaxis. Its etiology in regards to assorted elicitors resembling insect venoms, radiocontrast media, analgesics, common and native anesthetics is tested intimately. ultimately, remedy modalities for anaphylaxis are mentioned either for acute reactions and as common administration suggestions for sufferers in danger. supplying thorough and up to date assurance of this usually underestimated challenge, this publication is of curiosity not just to allergologists and immunologists, but in addition to all physicians and affected sufferers.

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Additional resources for Anaphylaxis (Chemical Immunology and Allergy, Vol. 95)

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1. Food allergens are the most frequent causes of anaphylaxis in children. Data from the anaphylaxis registry of German-speaking countries (ANA-Net), n = 70. % 60 50 40 30 Fig. 2. Venom is the most frequent causes of anaphylaxis in adults. Data from the anaphylaxis registry of Germanspeaking countries (ANA-Net), n = 734. 20 10 0 Insects Drugs Food Unknown SIT Others Latex [16]. The most frequent elicitators of food allergy in children are peanuts and tree nuts [17]. 2% [18]. Furthermore, in this study, food was identified as the most common cause of anaphylaxis.

There were a total of 3,019 drug-induced anaphylaxis hospital admissions between 1998 and 2005 reported from Australia [22]. Again, in prepuberty cases, males were more frequently affected and females outnumbered male subjects in the age groups >15 years. 8/100,000). In an evaluation of severe anaphylactic episodes, all with circulatory symptoms, performed in Switzerland, the frequency of drug reactions almost doubled that of reactions due to food. Approximately half of the drugs were NSAIDs and antibiotics were the second most frequent drug offender [23].

New York, Global Medical Communications, 1994. 42 Smedegard G, Revenäs B, Arfors KE: Anaphylaxis in the monkey: hemodynamics and blood flow distribution. Acta Physiol Scand 1979;106:191. 43 Smith PL, Kagey-Sobotka A, Blecker ER, Traystman R, Kaplan AP, Gralink H, Valentine MD, Permut S, Lichtenstein LM: Physiologic manifestations of human anaphylaxis. J Clin Invest 1980;60:1072. 44 Stark BJ, Sullivan TJ: Biphasic and protracted anaphylaxis. J Allergy Clin Immunol 1986;78:76–83. 45 Sullivan TJ: Cardiac disorders in penicillin-induced anaphylaxis: association with intravenous epinephrine therapy.

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