By Harry G. Brittain
Even supposing the professional compendia outline a drug substance by way of its identification, purity, power, and caliber, they in most cases don't offer different actual or chemical info, nor do they checklist equipment of synthesis or pathways of actual or organic degradation and metabolism. Such info is scattered through the clinical literature and the records of pharmaceutical laboratories.Edited through the affiliate Director of Analytical study and improvement for the yank organization of Pharmaceutical Scientists, Analytical Profiles of Drug ingredients and Excipients brings this knowledge jointly in a single resource. The scope of the sequence has lately been multiplied to incorporate profiles of excipient fabrics.
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Extra info for Analytical Profiles of Drug Substances and Excipients, Vol. 28
7 Hygroscopicity At a temperature of 25"C, anhydrous citric acid absorbs insignificant amounts of water when stored at relative humidities between about 25% and 50%. However, at relative humidities in the range of 50 - 75%, it absorbs significant amounts and the monohydrate phase is formed at relative humidities approaching 75%. At relative humidities greater than 75% substantial amounts of water are absorbed by the monohydrate. The hydrated acid is slightly deliquescent in moist air. At relative humidities less than about 65%, citric acid monohydrate effloresces at 25°C.
5) [M + 1 (H) - 90 (2 x C02H)I' CI (Isobutane) 46 H. POERWONO. K. HIGASHIYAMA, H. KUBO. T. K. SUDIANA, G. G. 1 Identification According to the United States Pharmacopoeia 24 , citric acid is identified by using a solution of the analyte responds to the test for Citrate (pyridine - acetic anhydride test) <191>. In addition to the citrate test, the Chinese pharmacopoeia  includes the test of igniting the crystal that should decompose gradually, but for which no caramel odor is perceptible (this is a distinction from tartaric acid).
Since an ISE mostly cannot be used for the direct determination of functional groups in organic substances (unless these substances are first converted into ionic species), direct potentiometry can be used only exceptionally. Very simple seivors can be used in the FIA technique, with citric acid forming complexes with Cu(I1) that can be determined with acceptable precision by using an indicator sensor consisting of a copper wire [ 5 3 ] . A bio-electrochemical determination of citric acid in fruits, juices, and sport drinks was reported by Prcldromidis et al .