By Kian Fan Chung

During this e-book, prime researchers in drugs and molecular pharmacology clarify the mobile mechanisms that regulate airway soft muscle. The capacity in which those are disrupted in sickness, and the pharmacologic recommendations in which they're transformed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity presents the clinician with the freshest details on one of many middle physiological approaches in airway disorder, and gives insights into present and destiny techniques to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most recent study to bronchodilator therapyMulti-contributed textual content, co-coordinated by means of of the top experts within the box.

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And Bel, E. H. (1989). Bronchial hyperresponsiveness: the need to distinguish between hypersensitivity and excessive airway narrowing. Eur Respir J 2, 267–274. Tao, F. , Eidelman, D. H. et al. (1999). Enhanced Ca2+ mobilization in airway smooth muscle contributes to airway hyperresponsiveness in an inbred strain of rat. Am J Respir Crit Care Med 160, 446–453. Tao, F. , Pradhan, A. A. et al. (2003). Enhanced calcium signaling to bradykinin in airway smooth muscle from hyperresponsive inbred rats.

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Am J Respir Cell Mol Biol 25, 569–576. Freyer, A. , Billington, C. , Penn, R. B. et al. (2004). Extracellular matix modulates ␤2 -adrenergic receptor signaling in human airway smooth muscle cells. Am J Respir Cell Mol Biol 31, 440–445. Gerthoffer, W. T. and Pohl, J. (1994). Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction. Can J Physiol Pharmacol 72, 1410–1414. Goldie, R. , Henry, P. J. et al. (1986). In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.

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