By Franz Joel Leong, Veronique Dartois, Thomas Dick

An annual dying toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of latest medications, higher diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and educating within the box of TB. It includes a hundred colour pictures and illustrations that deliver readability to the data provided. The atlas takes the weird technique of overlaying a number of species histopathology, arguably the 1st and rather almost certainly the one source to take action. It offers an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal versions. The editors have compiled details that is helping TB scientists to differentiate among the good points of all significant animal types to be had and to take advantage of them with their strengths and barriers in brain. The ebook presents counsel for choosing the simplest animal model(s) to reply to particular questions and to check the efficacy of drug applicants.

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The global burden of tuberculosis— Combating drug resistance in difficult times. N Engl J Med, 360, 2393–2395. Nathan, C. 2009. Taming tuberculosis: A challenge for science and society. Cell Host Microbe, 5, 220–224. S. 2008. Drugs versus bugs: In pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol, 6, 41–52. B. 2003. Tuberculosis: A problem with persistence. Nat Rev Microbiol, 1, 97–105. Chapter 3 Immunopathology of Tuberculosis Disease across Species Véronique Dartois Contents Overview of Species Specific Characteristics The Mouse The Rat The Rabbit and the Guinea Pig The Nonhuman Primate A Macroscopic View of TB-Infected Lungs across Species Summary and Lessons Learned References 21 21 22 22 23 24 26 27 M ycobacterium tuberculosis (MTB), the etiological agent of human TB, is closely related to all other members of the MTB complex, many of which are host adapted to a number of animal species.

M. 2003. Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis. Infect Immun, 71, 864–871. , 3rd. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun, 76, 2333–2340. J. 2009. Eliminating latent tuberculosis. Trends Microbiol, 17, 183–188. II 29 Chapter 4 Anatomy and Histology of the Human Lung F. -M. -Y. , 1984; Kayser, 1992; Hasleton and Curry, 1996; Colby and Yousem, 1997), and this chapter 31 32 ╛↜◾↜渀 A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis serves as a review of the basic features necessary to understand the functional and pathological changes that can occur in this organ.

These rings of hyaline cartilage can calcify and ossify with age. The noncartilaginous parts of the trachea are composed of a membrane of collagen and elastic fibers, the latter allowing recoil from stretching during breathing. In the main bronchi just proximal to the lobar bronchi, the cartilage is arranged circumferentially into irregular plates that decrease in size and density as they extend into the lung. With this decrease in cartilage mass is a concomitant increase in circular smooth muscle bundles to become the most prominent component in the wall of medium-sized bronchi, accounting for the efficient bronchoconstriction that occurs at this site.

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